Optical Coherence Tomography Assessment of Macular Thickness in Alzheimer’s Dementia with Different Neuropsychological Severities

This retrospective case-control study aimed to investigate associations between disease severity of Alzheimer’s dementia (AD) and macular thickness. Data patients with AD who were under medication (n = 192) 2013 2020, as well an age- sex-matched control group 200) normal cognitive function, included. divided into subgroups according scores the Mini-Mental State Examination (MMSE) Clinical Dementia Rating (CDR). Macular thickness was analyzed via Early Treatment Diabetic Retinopathy Study (ETDRS) grid map. had significant reductions in full macula layers, including inner circle, outer inferior area, nasal area macula. Similar retinal thinning noted ganglion cells plexiform layers. Advanced (MMSE score < 18 or CDR ≥ 1) showed more advanced reduction than (CDR 0.5 MMSE 18), indicating that severe impairment associated thinner is retina especially at circle may be a useful biomarker severity. Retinal imaging non-invasive, low-cost surrogate for AD.